Map - Santa Fe Province (Santa Fe Province)

The Province of Santa Fe (Provincia de Santa Fe, ) is a province of Argentina, located in the center-east of the country. Neighboring provinces are from the north clockwise Chaco (divided by the 28th parallel south), Corrientes, Entre Ríos, Buenos Aires, Córdoba, and Santiago del Estero. Together with Córdoba and Entre Ríos, the province is part of the economico-political association known as the Center Region.

Santa Fe's most important cities are Rosario (population 1,193,605), the capital Santa Fe (369,000), Rafaela (100,000), Reconquista (99,000) Villa Gobernador Gálvez (74,000), Venado Tuerto (69,000), and Santo Tomé (58,000).

The adult literacy rate in the province is 96.3%.

The aboriginal tribes who inhabited this region were the Tobas, Timbúes, Mocovíes, Pilagás, Guaycurúes, and Guaraníes. They were nomadic, lived from hunting, fishing and fruit recollection.

The first European settlement was established in 1527, at the confluence of the Paraná and Carcarañá rivers, when Sebastián Gaboto, on his way to the north, founded a fort named Sancti Spiritus, which was destroyed two years later by the natives.

In 1573 Juan de Garay founded the city of Santa Fe in the surroundings of present town Cayastá, but the city was moved in 1651 and 1660 to its present location.

In 1812 the lawyer and general Manuel Belgrano created and displayed for the first time the Argentine flag on the banks of the Paraná River, at Rosario (by that time a small village), 160 km south of Santa Fe.

In 1815, while Alvear's central government fell due to Ignacio Álvarez Thomas' rebellion (at that time commander of an army sent to Santa Fe against Artigas), Francisco Candioti, the local militia chief, took over the government peacefully, thus starting the era of Santa Fe as an autonomous province. This period was short lived, since that same year Candioti died and central government reestablished the dependent government. However, in 1816, the caudillos Mariano Vera and Estanislao López deposed the governor delegate and proclaimed the sovereignty of the province and its membership into Artigas's Free Peoples League (Liga de Pueblos Libres).

López drew, in 1818, a provincial constitution of a strongly conservative flavour, after rejecting a project proposed by a provincial assembly; Santa Fe was the first province to have its constitution. During the civil strifes of 1820, Santa Fe troops were decisive in the defeat of Buenos Aires' centralist army. So, in time, López gradually became the Federation's Patriarch, establishing himself as the central figure of the Federal Party until his death in 1838.

After López's death it was his secretary and right hand man, José María Cullen who was elected governor. However, Cullen being a potential rival of Buenos Aires governor and Confederation's Foreign Affairs Representative, Juan Manuel de Rosas, he sought and obtained Cullen's capture and execution, naming the pro-Rosas Juan Pablo López as governor. The new governor remained in power, alternating with Pascual Echagüe, until the province's invasion by Justo José de Urquiza's Great Army in 1851, and during his term the province adopted a new constitution in 1841.